Study Shows Circadian System Misalignment Impacts Insulin
The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, according to a study published online June 4 in Diabetes, Obesity and Metabolism.
The researchers found that circadian phase and circadian misalignment impact glucose tolerance through different mechanisms. The circadian system mainly decreases both dynamic and static β-cell responsivity to reduce glucose tolerance in the biological evening versus the biological morning. In contrast, circadian misalignment did not affect β-cell function but reduced glucose tolerance mainly by lowering insulin sensitivity.
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